Comparing World Health Organization/International Society of Urological Pathology Grading and Fuhrman Grading with the Prognostic Value of Nuclear Area in Patients with Renal Cell Carcinoma

This study was undertaken to compare Fuhrman grading with World Health Organization/International Society of Urological Pathology (WHO/ISUP) and stereologically measured nuclear area in patients Clear Cell Renal Carcinoma (ccRCC) or Papillary (PRCC) evaluate the independent predictive value Fuhrman, WHO/ISUP combined necrosis a series ccRCC relation cancer-specific survival. In all, 124 cases PRCC were included. All slides blindly scored by two trained pathologists according systems. Nuclear measurements performed on digitally scanned Visiopharm® correlated Analysis showed that application resulted significant downgrading from G2 G1, when comparing grading. Neither these experienced progression. Cancer specific survival estimates 101 slightly superior predicting Novel models included mean (MNA) each which necrosis. Both demonstrated an increased ability predict The demonstrates provides prognostic information compared area. Necrosis combination either MNA adds additional information.